If you are a woman between the ages of 40 to 65, and experiencing frequent hot flashes. You may qualify to be part of a research study called The REPLENISH Trial. Physicians in your area are conducting a no cost research study to evaluate the safety and effectiveness of an investigational medication for menopause- associated hot flashes and sweating. Qualified participants will receive free study related medical care, free medication plus compensation for time, travel, and expenses.